LrgpV1, Main, Exploration, bibRecord, 000A28

Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Identifieur interne : 000A28 ( Main/Exploration ); précédent : 000A27; suivant : 000A29

Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Auteurs : Malgorzata Geszke [France] ; Marek Murias [Pologne] ; Lavinia Balan [France] ; Ghouti Medjahdi [France] ; Jaroslaw Korczynski [Pologne] ; Michal Moritz [Pologne] ; Janina Lulek [Pologne] ; Raphaël Schneider [France]

Source :

Acta Biomaterialia [ 1742-7061 ] ; 2011-03.

RBID : Hal:hal-00798404

English descriptors

mix :
- AQUEOUS-SOLUTION, BIOLOGICAL APPLICATIONS, DOPED ZNS NANOPARTICLES, Folate, IN-VIVO, LIVING CELLS, LUMINESCENT NANOCRYSTALS, Luminescence, MN NANOCRYSTALS, Manganese-doped ZnS, PHOTOLUMINESCENCE, Quantum dots, SHELL, Targeting.

Abstract

This work presents a novel approach to producing water soluble manganese-doped core/shell ZnS/ZnS quantum dots (ZnS:Mn/ZnS). The Mn-doped ZnS core was prepared through a nucleation doping strategy and a ZnS shell was grown on ZnS:Mn d-dots by decomposition of Zn2+-3-mercaptopropionic acid (MPA) complexes at 100 degrees C. It was found that the Mn2+ T-4(1) -> (6)A(1) fluorescence emission at similar to 590 nm significantly increased after growth of the shell when the Mn2+ doping content was 4.0 at.%. A photoluminescence quantum yield of similar to 22% was obtained for core/shell nanocrystals. The nanoparticles were structurally and compositionally characterized by transmission electron microscopy. X-ray diffraction, X-ray photoelectron spectroscopy, and dynamic light scattering. The surface MPA molecules favor the dispersion of ZnS:Mn/ZnS QDs in aqueous media and make possible conjugation with targeting folic acid molecules. The folate receptor-mediated delivery of folic acid-conjugated ZnS:Mn/ZnS QDs was demonstrated using confocal microscopy with biphotonic excitation. Bare and folate-conjugated QDs exhibit only weak cytotoxicity towards folate receptor-positive T47D cancer cells and MCF-7 cells, used as a reference, at high concentrations (mmolar range) after 72 h incubation.

Url:

DOI: 10.1016/j.actbio.2010.10.012

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells</title>
<author><name sortKey="Geszke, Malgorzata" sort="Geszke, Malgorzata" uniqKey="Geszke M" first="Malgorzata" last="Geszke">Malgorzata Geszke</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Murias, Marek" sort="Murias, Marek" uniqKey="Murias M" first="Marek" last="Murias">Marek Murias</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216600" status="INCOMING"><orgName>Dept Toxicology</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Toxicology, PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Balan, Lavinia" sort="Balan, Lavinia" uniqKey="Balan L" first="Lavinia" last="Balan">Lavinia Balan</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106332" status="INCOMING"><orgName>Photomatériaux pour l'Optique et les Nanotechnologies</orgName>
<orgName type="acronym">PHOTON LRC 7228</orgName>
<desc><address><addrLine>IS2M 15 rue Jean Starcky 68057 Mulhouse</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-306818" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-306818" type="direct"><org type="institution" xml:id="struct-306818" status="INCOMING"><orgName>Université de Haute Alsace</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Medjahdi, Ghouti" sort="Medjahdi, Ghouti" uniqKey="Medjahdi G" first="Ghouti" last="Medjahdi">Ghouti Medjahdi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104710" status="VALID"><idno type="IdRef">152607595</idno>
<idno type="RNSR">200918462H</idno>
<idno type="IdUnivLorraine">[UL]RTA--</idno>
<orgName>Institut Jean Lamour</orgName>
<orgName type="acronym">IJL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Institut Jean Lamour, Parc de Saurupt, Rond-point Marguerite de Lorraine, CS 50840, 54011 NANCY cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ijl.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7198" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7198" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Korczynski, Jaroslaw" sort="Korczynski, Jaroslaw" uniqKey="Korczynski J" first="Jaroslaw" last="Korczynski">Jaroslaw Korczynski</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216601" status="INCOMING"><orgName>M. Nencki Inst Expt Biol, Lab Confocal Microscopy</orgName>
<desc><address><addrLine>Polish Acad Sci, M Nencki Inst Expt Biol, Lab Confocal Microscopy, PL-02093 Warsaw, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-300670" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300670" type="direct"><org type="institution" xml:id="struct-300670" status="VALID"><orgName>Polish Academy of Sciences</orgName>
<desc><address><country key="PL"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Moritz, Michal" sort="Moritz, Michal" uniqKey="Moritz M" first="Michal" last="Moritz">Michal Moritz</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216599" status="INCOMING"><orgName>Dept Pharmaceut Technol</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Pharmaceutical Technology PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Lulek, Janina" sort="Lulek, Janina" uniqKey="Lulek J" first="Janina" last="Lulek">Janina Lulek</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216599" status="INCOMING"><orgName>Dept Pharmaceut Technol</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Pharmaceutical Technology PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Schneider, Raphael" sort="Schneider, Raphael" uniqKey="Schneider R" first="Raphaël" last="Schneider">Raphaël Schneider</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00798404</idno>
<idno type="halId">hal-00798404</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00798404</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00798404</idno>
<idno type="doi">10.1016/j.actbio.2010.10.012</idno>
<date when="2011-03">2011-03</date>
<idno type="wicri:Area/Hal/Corpus">000525</idno>
<idno type="wicri:Area/Hal/Curation">000525</idno>
<idno type="wicri:Area/Hal/Checkpoint">000897</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000897</idno>
<idno type="wicri:doubleKey">1742-7061:2011:Geszke M:folic:acid:conjugated</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00786228</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00786228</idno>
<idno type="wicri:Area/Hal/Corpus">000526</idno>
<idno type="wicri:Area/Hal/Curation">000526</idno>
<idno type="wicri:Area/Hal/Checkpoint">000978</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000978</idno>
<idno type="wicri:doubleKey">1742-7061:2011:Schneider R:folic:acid:conjugated</idno>
<idno type="wicri:Area/Main/Merge">000B31</idno>
<idno type="wicri:Area/Main/Curation">000A28</idno>
<idno type="wicri:Area/Main/Exploration">000A28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells</title>
<author><name sortKey="Geszke, Malgorzata" sort="Geszke, Malgorzata" uniqKey="Geszke M" first="Malgorzata" last="Geszke">Malgorzata Geszke</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Murias, Marek" sort="Murias, Marek" uniqKey="Murias M" first="Marek" last="Murias">Marek Murias</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216600" status="INCOMING"><orgName>Dept Toxicology</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Toxicology, PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Balan, Lavinia" sort="Balan, Lavinia" uniqKey="Balan L" first="Lavinia" last="Balan">Lavinia Balan</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106332" status="INCOMING"><orgName>Photomatériaux pour l'Optique et les Nanotechnologies</orgName>
<orgName type="acronym">PHOTON LRC 7228</orgName>
<desc><address><addrLine>IS2M 15 rue Jean Starcky 68057 Mulhouse</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-306818" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-306818" type="direct"><org type="institution" xml:id="struct-306818" status="INCOMING"><orgName>Université de Haute Alsace</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Medjahdi, Ghouti" sort="Medjahdi, Ghouti" uniqKey="Medjahdi G" first="Ghouti" last="Medjahdi">Ghouti Medjahdi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104710" status="VALID"><idno type="IdRef">152607595</idno>
<idno type="RNSR">200918462H</idno>
<idno type="IdUnivLorraine">[UL]RTA--</idno>
<orgName>Institut Jean Lamour</orgName>
<orgName type="acronym">IJL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Institut Jean Lamour, Parc de Saurupt, Rond-point Marguerite de Lorraine, CS 50840, 54011 NANCY cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ijl.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7198" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7198" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Korczynski, Jaroslaw" sort="Korczynski, Jaroslaw" uniqKey="Korczynski J" first="Jaroslaw" last="Korczynski">Jaroslaw Korczynski</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216601" status="INCOMING"><orgName>M. Nencki Inst Expt Biol, Lab Confocal Microscopy</orgName>
<desc><address><addrLine>Polish Acad Sci, M Nencki Inst Expt Biol, Lab Confocal Microscopy, PL-02093 Warsaw, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-300670" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300670" type="direct"><org type="institution" xml:id="struct-300670" status="VALID"><orgName>Polish Academy of Sciences</orgName>
<desc><address><country key="PL"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Moritz, Michal" sort="Moritz, Michal" uniqKey="Moritz M" first="Michal" last="Moritz">Michal Moritz</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216599" status="INCOMING"><orgName>Dept Pharmaceut Technol</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Pharmaceutical Technology PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Lulek, Janina" sort="Lulek, Janina" uniqKey="Lulek J" first="Janina" last="Lulek">Janina Lulek</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-216599" status="INCOMING"><orgName>Dept Pharmaceut Technol</orgName>
<desc><address><addrLine>Karol Marcinkowski Univ Med Sci, Dept Pharmaceutical Technology PL-60780 Poznan, Poland</addrLine>
<country key="PL"></country>
</address>
</desc>
<listRelation><relation active="#struct-352874" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-352874" type="direct"><org type="institution" xml:id="struct-352874" status="INCOMING"><orgName>Karol Marcinkowski University of Medical Sciences, Poznan</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Pologne</country>
</affiliation>
</author>
<author><name sortKey="Schneider, Raphael" sort="Schneider, Raphael" uniqKey="Schneider R" first="Raphaël" last="Schneider">Raphaël Schneider</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.actbio.2010.10.012</idno>
<series><title level="j">Acta Biomaterialia</title>
<idno type="ISSN">1742-7061</idno>
<imprint><date type="datePub">2011-03</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>AQUEOUS-SOLUTION</term>
<term>BIOLOGICAL APPLICATIONS</term>
<term>DOPED ZNS NANOPARTICLES</term>
<term>Folate</term>
<term>IN-VIVO</term>
<term>LIVING CELLS</term>
<term>LUMINESCENT NANOCRYSTALS</term>
<term>Luminescence</term>
<term>MN NANOCRYSTALS</term>
<term>Manganese-doped ZnS</term>
<term>PHOTOLUMINESCENCE</term>
<term>Quantum dots</term>
<term>SHELL</term>
<term>Targeting</term>
</keywords>
<keywords scheme="mix" xml:lang="pt"><term>Folate</term>
<term>Luminescence</term>
<term>Manganese-doped ZnS</term>
<term>Quantum dots</term>
<term>Targeting</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This work presents a novel approach to producing water soluble manganese-doped core/shell ZnS/ZnS quantum dots (ZnS:Mn/ZnS). The Mn-doped ZnS core was prepared through a nucleation doping strategy and a ZnS shell was grown on ZnS:Mn d-dots by decomposition of Zn2+-3-mercaptopropionic acid (MPA) complexes at 100 degrees C. It was found that the Mn2+ T-4(1) -> (6)A(1) fluorescence emission at similar to 590 nm significantly increased after growth of the shell when the Mn2+ doping content was 4.0 at.%. A photoluminescence quantum yield of similar to 22% was obtained for core/shell nanocrystals. The nanoparticles were structurally and compositionally characterized by transmission electron microscopy. X-ray diffraction, X-ray photoelectron spectroscopy, and dynamic light scattering. The surface MPA molecules favor the dispersion of ZnS:Mn/ZnS QDs in aqueous media and make possible conjugation with targeting folic acid molecules. The folate receptor-mediated delivery of folic acid-conjugated ZnS:Mn/ZnS QDs was demonstrated using confocal microscopy with biphotonic excitation. Bare and folate-conjugated QDs exhibit only weak cytotoxicity towards folate receptor-positive T47D cancer cells and MCF-7 cells, used as a reference, at high concentrations (mmolar range) after 72 h incubation.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Pologne</li>
</country>
<region><li>Grand Est</li>
<li>Lorraine (région)</li>
</region>
<settlement><li>Metz</li>
<li>Nancy</li>
</settlement>
<orgName><li>Université de Lorraine</li>
</orgName>
</list>
<tree><country name="France"><region name="Grand Est"><name sortKey="Geszke, Malgorzata" sort="Geszke, Malgorzata" uniqKey="Geszke M" first="Malgorzata" last="Geszke">Malgorzata Geszke</name>
</region>
<name sortKey="Balan, Lavinia" sort="Balan, Lavinia" uniqKey="Balan L" first="Lavinia" last="Balan">Lavinia Balan</name>
<name sortKey="Medjahdi, Ghouti" sort="Medjahdi, Ghouti" uniqKey="Medjahdi G" first="Ghouti" last="Medjahdi">Ghouti Medjahdi</name>
<name sortKey="Schneider, Raphael" sort="Schneider, Raphael" uniqKey="Schneider R" first="Raphaël" last="Schneider">Raphaël Schneider</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Murias, Marek" sort="Murias, Marek" uniqKey="Murias M" first="Marek" last="Murias">Marek Murias</name>
</noRegion>
<name sortKey="Korczynski, Jaroslaw" sort="Korczynski, Jaroslaw" uniqKey="Korczynski J" first="Jaroslaw" last="Korczynski">Jaroslaw Korczynski</name>
<name sortKey="Lulek, Janina" sort="Lulek, Janina" uniqKey="Lulek J" first="Janina" last="Lulek">Janina Lulek</name>
<name sortKey="Moritz, Michal" sort="Moritz, Michal" uniqKey="Moritz M" first="Michal" last="Moritz">Michal Moritz</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/LrgpV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A28 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A28 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Lorraine
   |area=    LrgpV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:hal-00798404
   |texte=   Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells
}}

This area was generated with Dilib version V0.6.32.
Data generation: Sat Nov 11 15:47:48 2017. Site generation: Wed Mar 6 23:31:34 2024

Serveur d'exploration sur le LRGP

Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur le LRGP
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.